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In addition, more CD4 + T cells expressed interferon- and interleukin (IL)-2, and increased plasma levels of IL-6, macrophage inflammatory protein 1, IL-1, tumor necrosis factor-alpha and the soluble IL-1 receptor antagonist in the Long COVID patients [59, 62, 63, 67,68,69,70], indicating activation of M1 macrophages and T helper (Th)-1 phenotypes [33]

A 2024 systematic review published in a peer-reviewed orthopaedic journal acknowledged these findings while flagging a critical limitation: there are no completed Phase III clinical trials in humans

Clin Rev Allergy Immunol 66(2):250259

Once everything was in place, the company quickly began to expand

GHK-Cu Patient Information Document.