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Neuro-imaging studies focusing on individuals with post-acute sequelae of COVID-19 (PASC) have revealed significantly lower-than-normal glutathione levels specifically localized in the frontal gray matter of the brain

However, Prevotella colonization reduces SCFA production, increases susceptibility to mucosal inflammation, and stimulates immune cells to secrete inflammatory mediators [68, 69]

Actinobacteria were widely distributed, produced abundant secondary metabolites, and played an important role in the energy cycle of ecosystems [34,35]

These features greatly limit GSH accumulation

Furthermore, reduction in bioavailable NO induces pathogenic vascular smooth muscle cell proliferation in vitro and vasoconstriction in vivo due to suppression of cGMP kinase signaling 40,41