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Specifically, IL-1 is constitutively produced and retained in keratinocytes, but in response to several stimuli, IL-1 is released, which is essentially a primary event of inflammation

10.1038/s42255-020-00305-3 [DOI] [PMC free article] [PubMed] [Google Scholar] Deryabin Pavel I., Shatrova Alla N., Borodkina Aleksandra V

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38 HageC.RauschV.GieseN.GieseT.SchnsiegelF.LabschS.et al (2013)

While the total drug exposure remained comparable across all three sites, the thigh produced fewer acute gastrointestinal side effects in the study participants