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Additionally, some researchers have found that there is inadequate ACE2 activity.[ref][ref] Vasoconstriction and POTS: Vasoconstriction is the tightening (constriction) of blood vessels, which increases blood pressure

PMC 5756557

S., et al

Eight weeks is a long enough window to observe effects, and four weeks off is a real break that gives the methylation cycle time to normalize before the next block