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Since the helix D1 constituted a part of the entrance to the ligand-binding pocket, it is suggested that the orientation of helix D1 affected the size of the ligand-binding pockets, and thus the helix D1 might be an important structural determinant for the ligand- binding specificity

Sack, R

The recent COVID-19 crisis shed new light on the relevance of the concept which inspired numerous ideas of application