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Participants who choose to quit set a quit date approximately 1 week later and return to the study center after an approximately 24-hour period of abstinence so that the severity of their withdrawal can be assessed prior to dosing NRT

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Principle Dialysate is infused into the peritoneal cavity Waste diffuses from blood into dialysate Fluid removed by osmotic gradient (glucose) Types Continuous Ambulatory Peritoneal Dialysis (CAPD) Automated Peritoneal Dialysis (APD) Access Permanent Tenckhoff catheter inserted into the abdomen Advantages Can be done at home More stable hemodynamics Greater patient independence No need for vascular access Complications Peritonitis (cloudy effluent, abdominal pain) Catheter infection Protein loss Weight gain Hyperglycemia Key Differences (Clinical Emphasis) HD uses an external machine