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The acronym, NAT, is the more broad-spectrum arylamine N-acetyltransferase that also acetylates serotonin, which allows for the production of melatonin in species that are deficient in AANAT and incorrectly defined as melatonin knock out ( Figure 1 Quay was the first to document that pineal melatonin synthesis was cyclic and that its production was clearly higher at night than during the day ( Figure 1 )

Millan, M

has received PHRC grants from the French Ministry of Health (PHRC and ANR), European grants (H2020 and Coen) and research funding from the ARSLA charity, France

Birth control pills (contraceptives) containing estrogen and progesterone and hormone replacement therapy may also contribute to melasma flare-ups

Baek MO et al (2018) Differential regulation of mTORC1 and mTORC2 is critical for 8-Br-cAMP-induced decidualization