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Several medications interact with Tadalafil and should either not be taken while you are taking Tadalafil or only after discussion and instruction from your doctor: Drugs that cause a serious reaction with Tadalafil: any nitrate medication, such as nitroglycerin for angina Drugs that affect Tadalafil: antibiotics like erythromycin and rifampicin, antifungals like itraconazole or ketoconazole, antacids, ritonavir or saquinavir for HIV Drugs that are affected by Tadalafil: non-selective alpha-blockers like doxazosin for high blood pressure, tamsulosin and prazosin for enlarged prostate, nitrates such as glyceryl trinitrate for angina and other heart conditions, drugs for high blood pressure (may need dose adjustment) How should Tadalafil be taken

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