glutathione autoimmune disease Glutathione: A Little Miracle for Your Health The Importance of Glutathione in

Spine (Phila Pa 1976) 2010;35(7):E231237

It is known that Down patients suffer from mild to moderate oxidative stress due to the overexpression of the Cu-Zn superoxide dismutase (SOD) gene that is also located on chromosome 21 [62]

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Empagliflozin, an inhibitor of sodium-glucose cotransporter 2 (SGL2) that is used to lower blood sugar levels in type-2 diabetes patients, attenuates diabetic kidney damage by reducing ferroptosis through its effect on the AMPK/NRF2 axis [249]

Breast milk provides passive immunity and mucosal defense through secretory IgA, lactoferrin, and lysozyme, which form a protective barrier in the infants gut and limit systemic exposure to pathogens and dietary antigens, thereby reducing excessive immune stimulation [14, 15]