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Signals in an AMPKdependent manner, amplifying glucose uptake, inhibiting the folate cycle and de novo purine biosynthesis during metabolic stress, and shifting cellular metabolism toward enhanced stress resilience and efficient fuel use

The combination can benefit a wide range of individuals: Men over 40 with declining hormone levels: Both testosterone and GH decline with age, and addressing both creates a more comprehensive optimization strategy

PMID 11994745

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