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At the periphery, the production of neopterin and nitric oxide during inflammation consumes tetrahydrobiopterin to the detriment of the hydroxylase enzymes that use this compound as a cofactor.[ref] Genetic variants can also significantly influence BH4 levels when the body is under stress

While this may support Muscle growth or Muscle recovery, overstimulation can lead to side effects such as joint discomfort, swelling, headaches, or fatigue

Vitamin B12 deficiency can cause fatigue, weakness, anemia, and dizziness

[DOI] [PubMed] [Google Scholar] May M

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