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versus 92.9% when 0.1 ng/mL was used as the cutoff) had ETS exposure, corresponding to similar values as observed under the initial operationalization: PPV of 85.7%, NPV of 26.6%, sensitivity of 27.7%, and specificity of 85.0%, and = 0.072 (95% CI: 0.04, 0.18)

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Melanocyte stimulation by nicotine and benzopyrenes Nicotine and benzopyrenes, chemical compounds present in all tobacco products, directly activate the pigment-producing cells in your lip tissue