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R The key catalytic mechanism involves lowering the pKa of the glutathione thiol from 9.0 to approximately 6.5, generating the thiolate anion (GS) at physiological pH, which is a potent nucleophile

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For example, the hydroxyl group can undergo glucuronic acid conjugation, sulfate conjugation and acetylation reactions

Inhibition of melanin dispersion Following melanin synthesis, one key step of melanogenesis in the skin is the translocation of mature melanosomes into keratinocytes, which are then transported up to the epidermidis where the melanin is dispersed