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This often includes older adults, as stomach acid productionwhich is essential for B12 absorptiontends to decrease with age

The answer, as with all things in research, is: it depends on the model and the objective

But thats not the world we live in

Trials conducted between 2001 and 2007 demonstrated statistically significant reductions in body fat, although the larger Phase IIb OPTIONS trial did not replicate these findings at sufficient magnitude for regulatory approval, and formal development was discontinued in 2007