doi: 10.3389/fcell.2025.1559300 Received 12 January 2025 Accepted 29 May 2025 Published 09 June 2025 Volume 13 - 2025 Edited by Ariane Zamoner, Federal University of Santa Catarina, Brazil Reviewed by Belm Sampaio-Marques, University of Minho, Portugal Heidar Heidari Khoei, Austrian Academy of Sciences (OeAW), Austria Updates Copyright 2025 Khodaei, Noori, Zare and Meshkin
The principal regulatory mechanisms of ferroptosis involve lipid peroxidation, amino acid metabolism, oxidative stress, iron ion homeostasis, and various organelles, all of which are prerequisites for the occurrence of ferroptosis
Extrapolating brain development from experimental species to humans
Now, if that superoxide has been generated outside the mitochondria, which is very possible because you do have enzymes that produce superoxide outside the mitochondria for various purposes
The qPCR cycling conditions were as follows: an initial denaturation at 95 C for 15 min, followed by 30 cycles of 95 C for 7 s and 58 C for 10 s, and a final extension step at 95 C for 5 min, then 40 cycles of 95 C for 15 s and 58 C for 30 s