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Diabetes Research and Clinical Practice, 161 , 108087

424 Moreover, the two components of the G3P shuttle (including GPD1 in the cytoplasm and GPD2 in the mitochondria) are up-regulated in mRNA and protein levels in diabetic islets, thus ensuring the transfer of electrons from NADH produced in glycolysis to mitochondria

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Two oligopeptides P3 , an octapeptide (Arg-Ala-Asp-ser-Arg-Ala-Asp-Cys) and a decapeptide P4 (Tyr-Arg-ser-Arg-Lys-Tyr-Ser-Ser-Trp-Tyr) showed substantial inhibitory effects on mushroom and human tyrosinase with IC 50 value of 123 and 40 M, compared with hydroquinone