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Benedetto J-P, Ortonne J-P, Voulot C, Khatchadourian C, Prota G, Thivolet J

The standard phase typically lasts 2 to 4 months and is when most measurable results occur

Recent research shows that the microenvironment in which chronic inflammation takes place is largely like the tumor microenvironment

These studies will provide crucial experimental evidence for constructing a combined intervention strategy of gut microbiota-ferroptosis axis, and contribute to clarifying the causal relationship and molecular synergistic mechanism between gut microbiota dysbiosis and cartilage ferroptosis

Multiple CNS cell types, including microglia, astrocytes, and vascular cells, contribute to neuroinflammation, alongside disruption of the BBB (Figure 3)