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Simultaneously, PSP exhibited potential to ameliorate depressive-like behavior by inhibiting ERK phosphorylation-mediated NF-B activation and modulating inflammatory responses (Shen et al., 2021)

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Zinc also supports ER redox homeostasis by bolstering antioxidant defenses, including MTs and reactive oxygen species (ROS)-detoxifying enzymes such as glutathione peroxidase and peroxiredoxins 60

The systemic contribution from injection reduces the need for aggressive topical concentration