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Ipamorelin may not be the right choice if you: Have active cancer Have uncontrolled diabetes or significant blood sugar issues Are pregnant or breastfeeding Have severe heart disease How to Reduce Ipamorelin Side Effects You can take steps to make peptide therapy easier on your body: Start with a low dose and increase slowly Rotate injection sites to minimize irritation Take it in the evening if you feel drowsy Stay hydrated and watch sodium if you notice bloating Get regular labs to monitor glucose, insulin sensitivity, and overall health Comparing Ipamorelin to Other Peptides Heres a quick look at how ipamorelin stacks up against other common peptides when it comes to side effects: Ipamorelin is often considered the more gentle option, especially compared to MK-677, which is notorious for causing stronger appetite and fluid retention