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Plasma concentrations measure around 200 ng/mL at age 20 and drop to roughly 80 ng/mL by age 60 a decline of more than 60%

doi: 10.3109/02713688209020005

The role of methionine supplementation on oxidative stress and antioxidant status of poultrya review

While its safety profile was consistently favorable, the largest Phase IIb trial failed to show statistical significance for weight loss, and commercial development was halted in 2007.[2] Despite this, interest in AOD-9604 has continued in the compounding pharmacy and integrative medicine space, particularly given its safety data, its lack of IGF-1 stimulation, and emerging research around joint health

It was named after early rabbit experiments involving delta-wave EEG activity