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8 Interventions based on treatment with hydroxyurea (hydroxycarbamide) have shown a certain degree of efficacy in upregulating the expression of fetal hemoglobin (HbF) and increasing mean corpuscular volume, 10 while decreasing the frequency of pain episodes and other acute complications in adults and children with sickle cell anemia of SS or Sthal genotypes, reducing the incidence of life-threatening neurological events such as primary stroke by maintaining transcranial Doppler velocities

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