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In an embryofetal development study with pregnant rats dosed by the inhalation route throughout the period of organogenesis, fluticasone propionate produced decreased fetal body weights and skeletal variations, in the presence of maternal toxicity, at a dose approximately 0.3 times the MRHDID (on a mcg/m2 basis with a maternal inhalation dose of 25.7 mcg/kg/day)

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The Poynter Institute

Increased SNS activity leads to bone loss through increased bone resorption and decreased bone formation mediated by 2-adrenergic influence on osteoblastic and osteoclastic cells (Kim et al., 2017)

Of the entire Oliver Twist variety, I find these to have the best flavor