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However, a notable side effect was observed: MT-II-treated normal C57BL/6J mice exhibited significant weight loss, with their average weight decreasing from a baseline of 30.9 1.4 grams to 26.5 1.7 grams after the 14-day treatment course, a change not seen in vehicle-treated controls

In one study 10 , elderly mice treated with 5-Amino-1MQ showed: ~40% stronger grip strength in sedentary conditions ~20% improvement with exercise ~60% boost when combined with exercise + therapy This suggests powerful benefits for maintaining strength and resilience with age

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