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We assessed the differences in demographic measures between the two groups at baseline using chi-square tests

This fragmentation slows hypothesis generation, delays mechanistic validation, and weakens the iterative bench-to-bedside process needed to translate molecular findings into meaningful clinical outcomes

Additionally, -sitosterol inserted into the lipid bilayer of PEG-LNPs induces the formation of polyhedral particle shapes, which increase membrane contact area and promote membrane destabilization, thus enhancing endosomal escape after cellular uptake 172

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These include the nitric oxide (NO) signaling system, angiogenic responses via VEGFR2, and antioxidant defense mechanisms involving HO-1 and other key enzymes (Jzwiak et al