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Au vu des donnes disponibles, le mcanisme serait le suivant : par des mcanismes et voie encore mal compris, mais qui incluent une augmentation anormale des espces ractives de l'oxygne, des rponses intercellulaires anormales et une perturbation de la fonction mitochondriale induisent une perturbation de l'homostasie de l'organelle [102]