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10.1016/j.bpobgyn.2010.10.011 102 PsychoyosA

Oxidized GSH (GSSG) is reduced back to GSH by GSR in an NADPH-dependent manner, thereby sustaining cellular antioxidant defense and linking redox buffering to central metabolic pathways that generate NADPH, such as the PPP and IDH-dependent reactions

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BBB dysfunction was associated with neurological impairment during the active phase of SARS-CoV-2 infection, with increased serum levels of the astrocytic protein S100 together with increased levels of IL-6, bFGF and IL-13 suggesting that a heightened systemic inflammatory response may drive BBB dysfunction