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However, their effect may be particularly dose-dependent and more research is needed before specific recommendations can be made

Exclusion of conditions that mimic APD: Several disorders can worsen premenstrually and must be ruled out, including: Chronic eczema or contact dermatitis Premenstrual flares of inflammatory skin conditions PMDD-related skin changes without immune involvement Mast cell activation disorders or systemic mastocytosis Drug reactions unrelated to hormonal timing Thorough medication and hormone exposure history: Identifying symptom onset after exposure to: Progestin-containing birth control Fertility medications Progesterone creams or suppositories can help distinguish exogenous from endogenous progesterone hypersensitivity

10.1038/ncb3234 59 KanekoT.HuangH.CaoX.LiX.LiC.VossC.et al (2012)

Preferred Dosage Gary Brecka uses about 1.5 grams (1500 mg) of liposomal creatine daily (source), but for most individuals, a dose of 35 grams of creatine monohydrate per day is standard

Blood 1997