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Functional Variants in the Glutathione Peroxidase-1 (GPx-1) Gene Are Associated with Increased Intima-media Thickness of Carotid Arteries and Risk of Macrovascular Diseases in Japanese Type 2 Diabetic Patients

Studies have reported the toxic effect of PFOS on RTCs

Cell 146 , 772784 (2011)

Typically, the catalytic cysteine is exposed to the solvent, while the resolving cysteine is buried, a pattern that is also observed for GRXC2 and ROXY9 (Supplementary Table 1)

However, these processes generate considerable amounts of reactive oxygen species (ROS), oxidative stress, and toxic dicarboxylic acids, potentially promoting inflammation and disease progression [78] (Fig