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The design strategy and mechanism were outlined in Fig

Total observed flux can also be shaped by fatty acid delivery, albumin binding, acyl-CoA synthetase activity, CACT transport, CPT2 activity, -oxidation enzyme capacity, TCA cycle activity, electron transport chain function, mitochondrial coupling, and cell viability

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While the protection of normal cells against radiation-induced cell death by ebselen has been attributed to its ability to detoxify cellular/mitochondrial ROS through the GPx mechanism, the molecular mechanism contributing to its radio-sensitization effect in cancer cells is still not fully understood

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