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Over time, there is a loss of elasticity in the lung due to oxidative stress, apoptosis and protease expression [4]

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The process of heating and inhaling cocaine vapor leads to rapid absorption into the bloodstream, intensifying both the high and the associated risks

[151] Other studies suggest broader neuronal recovery, such as normalization of dopamine transporter (DAT) levels in reward centers, may extend up to 1214 months in some cases of substance dependence affecting dopamine levels, though specific data for nicotine are limited