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Targeting apoptosis in acute tubular injury

3 The mechanism of action of Tan IIA on DOX-induced cardiotoxicity 3.1 Antioxidant stress Oxidative stress is widely recognized as a primary mechanism underlying DOX-induced cardiomyopathy (48, 49)

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In addition, ROS production and changes in mitochondrial membrane potential are associated with ferroptosis, so we examined the levels of intracellular ROS, as well as mitochondrial membrane potential changes

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