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The ability of NRF2 to regulate xCT coupled with the decline of NRF2 with age 178 might account for the increased levels of plasma cystine seen with increasing age

Pathogenesis of important virulence factors of Porphyromonas gingivalis via toll-like receptors

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Hepatic fibrosis, a dynamic and potentially reversible process, arises from chronic liver injury where immune cells and hepatic stellate cells drive excessive extracellular matrix deposition

Our previously used concentrations of sertraline in pre-clinical in vivo experiments with anti-cancer effects can be extrapolated to the concentrations used in humans, showing a therapeutic index of sertraline that could support future clinical trials [19, 23, 24]