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Apart from the antioxidant protections, a trial on oral supplementation during the periods of high-intensity exercises also showed benefits in the modulation of inflammatory signaling, the pro- and anti-inflammatory cytokines released, together with a potential pro-angiogenic effect on hematologic parameters such as hemoglobin, red blood cell number, vascular endothelial growth factor (VEGF), and epidermal growth factor (EGF) [74]

In the methionine cycle, 5-mTHF relays the one-carbon units to homocysteine to generate methionine, which can be then used for S-adenosylmethionine (SAM) formation (Fig

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