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30 min (estimated) + approx

Mitochondrial dysfunction in autism spectrum disorders: a systematic review and meta-analysis

In addition to the PERK-ATF4-CHOP axis, other key ER stress pathways, such as IRE1/XBP1 and ATF6 also contribute to the UPR, collectively managing protein misfolding and restoring homeostasis, or, if stress persists, trigger cell death (Tabas and Ron, 2011)

Akt phosphorylation by insulin is impaired in Insr P1195L/ + /HFD mice, both in WAT and in liver P1195L/ + Insulin inhibits lipolysis in adipocytes and gluconeogenesis in hepatocytes