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Indicators of a substance use problem may include: Loss of interest in activities once enjoyed Frequent changes in friends Neglecting personal care Spending more time alone than usual Changes in eating habits Disrupted sleep patterns Difficulties at work or with family Irritability or mood swings Intense cravings for the substance Strategies for Preventing Alcohol and Substance Abuse: Educate Yourself : Increase your knowledge about how substance abuse develops and the factors that contribute to it