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Suggested Use Take 1 mL (approximately 2 pumps) twice daily and hold in mouth for 30 seconds before swallowing, or as directed by your health-care practitioner

It means there's limited formal evidence on safety, and caution is warranted

Real-World Exposure Assessment: Evaluating the synergistic effects of multiple EED exposure to better reflect actual human environmental conditions and improve risk prediction accuracy

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Shouval HZ, Bear MF, Cooper LN (2002) A unified model of NMDA receptor-dependent bidirectional synaptic plasticity