EGF is bioactive but barrier-limited: the molecule does what it does only if it reaches the keratinocyte layer, and standard topical formulations deposit most of it on the stratum corneum where it has no relevant receptor
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A publicly available single-nuclei RNA-Seq (snRNAseq) data set (GSE223581) containing healthy human liver samples ( n = 9) and AILI liver samples ( n = 11) was used to identify the expression of DDIT4 in AILI human liver samples [34]