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The scientific discipline of epidemiology has been the major tool to hypothesize and evaluate genetic, epigenetic, prenatal, perinatal, and environmental factors

It often coexists with POTS and shares mechanisms like mitochondrial dysfunction, systemic inflammation, and oxidative stress

GI, gastrointestinal tract

At the molecular level, it modulates the expression of over 4,000 human genes, roughly 6% of the genome, according to a 2012 Broad Institute Connectivity Map analysis published by Pickart, Campbell, and colleagues

Prklinische toxikologische Daten: Die Studien zur akuten und subakuten Toxizitt bei der Ratte haben weder Mortalitt noch signifikante Organtoxizitt ergeben, selbst bei Dosen, die weit ber den therapeutischen Dosen lagen (bis zum 100-Fachen der wirksamen Dosis)