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Huijbers MG, Zhang W, Klooster R, Niks EH, Friese MB, Straasheijm KR, et al

SOD exerts antioxidant roles by catalyzing the transformation of O 2 into H 2 O 2 , which can be scavenged to H 2 O via enzymes such as peroxiredoxin

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The significance of this is that ferritin and hepcidin sequester iron intracellularly, resulting in formation of ROS, reactive nitrogen species (RNS), and reactive sulfur species and may contribute to tissue damage in the lungs and other involved organs [47,48]

Regular exercise also improves sleep, reduces anxiety, and addresses the depression that often underlies alcohol use disorder