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Regulatory and commercial factors rather than safety concerns explain this limitation

Hematology Reports 5 (1), 2333

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In addition, evidence has been provided that Nrf2 silencing can sensitize colon cancer models to cell death induced by anti-tumour agents [88]

Chronic wounds are typically covered with inflammatory exudates and biofilms 25 , which constitute a physicochemical barrier hindering the penetration of topical therapeutic agents into the underlying live tissues