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A: Alternatives to estradiol patches include FDA-approved transdermal gels and sprays, oral estradiol (with a different clot-risk profile), vaginal estrogen preparations for genitourinary symptoms, and compounded transdermal estradiol creams from PCAB-accredited pharmacies
[DOI] [PubMed] [Google Scholar] [181].Casey PG, Gardiner GE, Casey G, Bradshaw B, Lawlor PG, Lynch PB, et al
Tom Brunner: Well, certainly as we all, I like to say as we all get less young there definitely is this increase in age-related diseases, as you point out, and being able to solve that could be a huge contribution
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These changes can cause oxidative modifications to reactive thiols of structurally- or functionally-critical proteins, such as transcription factors 43 , signal transduction molecules 44 or metabolic enzymes 45 , and thereby evoke cellular defense mechanisms against oxidative damage 46
