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If results stall despite adherence and compound integrity is verified, 5-amino-1MQ becomes a reasonable second-line addition

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Published penetration studies using radiolabeled tracers have confirmed dermal absorption after topical application

Patients with controlled uric acid level and doing well on allopurinol would seem to have no reason to switch to this new agent, in view of allopurinol's lower cost and 40-year history of an overall very good safety record (see "Allopurinol" discussion above)

21 Thus, therapeutic approaches for iron overload include direct or indirect modulation of hepcidin expression to reduce iron absorption