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The most commonly reported adverse effects were mild to moderate headache and gastrointestinal symptoms including diarrhea, flatulence, nausea, and increased appetite

However, we consider ASD a necessary term given the description in the Diagnostic and statistical manual of mental disorders (DSM-5)

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The Nervous Systems Role in Chronic Pain Central Sensitization: When the Brain Amplifies Pain Chronic pain is not solely a tissue problemit is also a nervous system problem