The main reason is receptor desensitization : continuous stimulation of the same receptor makes cells less responsive over time, so a planned off period lets the receptor resensitize
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The TGA's formal position, outlined in a media release, was that compounded semaglutide posed patient safety risks related to dosing accuracy, sterility, and the use of unapproved salt forms (particularly semaglutide sodium rather than the free acid form used in approved products)
Some men find weekend dosing preferable, managing any symptoms on days without work obligations