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In REDEFINE 2, 73.5% of CagriSema participants reached HbA1c 6.5% versus 15.9% on placebo (treatment-policy estimand)

If side effects are persistent, if pancreatitis risk is a concern, or if weight or cardiovascular goals point in another direction, clinicians may consider alternatives from other drug classes

Different peptides target different biological pathways, which is why the field covers everything from tissue repair to hormone improvement to immune modulation

Endothelial tube-formation and aortic-ring angiogenesis assays with VEGF/eNOS readouts

Moreover, the peptide is administered via intramuscular or subcutaneous injections , which for some can be problematic, painful, or simply controversial