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GPX4 can also be turned off directly by squalene synthase, HMG CoA reductase, and other enzymes, which can change reduction reactions (75)

With the aid of tyrosinase-related protein 2, dopachrome is then converted into 5,6-dihydroxyindole-2-carboxylic acid (DHICA), and 5,6-dihydroxyindole (DHI) (Olivares et al., 2001)

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