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In the human knee joint, the selenium concentration in cartilage is approximately 80 g/kg dry weight, whereas the selenium concentrations in ligament and meniscus are 270 and 307 g/kg dry weight, respectively 60,61

Inflammation engulfs a substantial amount of oxygen, leading to hypoxia and acidic conditions in the 1 system [13], which subsequently triggers the generation of reactive oxygen species (ROS), angiogenesis, and infiltration by inflammatory cells

Funding The work was funded by National Key Research and Development Program of China (2022YFA1105300 and 2022YFE0138700), National Natural Science Foundation of China (82325036, 82325002, 82200954, 82573909, 82503219 and 82472753) and Fundamental Research Funds for the Central Universities, Sun Yat-sen University (23ykzy004)

Bacteria as vitamin suppliers to their host: a gut microbiota perspective