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10.1271/bbb.70474 Biosci

Although the effects of iron on the macrophage depend, among other things, on the iron source, concentration, exposure time and cellular context, studies generally show that iron supplementation induces a M1-like phenotype with pro-inflammatory cytokine production and ROS generation (90, 95100)

Certain groups are more likely to develop a B12 deficiency, including: Vegans and vegetarians B12 is found primarily in animal products

A distinct biological advantage All mammalian cells secrete IGF Binding Proteins (IGFBPs) which bind to and inhibit native IGF-I

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