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In vitro barrier models using Caco-2 cells (gut epithelium) or brain endothelial cells could be employed to test the hypothesis that microbiota metabolites, such as butyrateeither administered directly or derived from patient-derived fecal microbiota culturescan strengthen epithelial and endothelial barrier function and reduce oxidative stress [40]

doi: 10.1002/mnfr.200400098 158 MacCarroneMLorenzonTGuerrieriPAgrAF

At the time of this publication two drugs targeted at the glutamatergic system, Riluzole and Edaravone, are the only FDA approved drugs to slow the progression of ALS

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This resulted in additional oral ingestion of dichlorvos (Stevenson & Blair, 1977)