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By June 2021, synthetic opioids were involved in an estimated 87% of opioid deaths and 65% of all drug overdose deaths.(5) This has made opioid overdose a leading cause of death in the United States.(6) Figures 1 and 2: NIDA, Drug Overdose Deaths: Facts and Figures, Fentanyl Fentanyl is 50 times more potent than heroin and 100 times more potent than morphine